Metabolic activation and binding of mitotane in adrenal cortex homogenates.

@article{Cai1995MetabolicAA,
  title={Metabolic activation and binding of mitotane in adrenal cortex homogenates.},
  author={W. Cai and R. Counsell and T. Djanegara and D. Schteingart and J. Sinsheimer and L. Wotring},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 2},
  pages={
          134-8
        }
}
Mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, o,p'-DDD] is an adrenocorticolytic agent of value in the treatment of adrenocortical carcinoma and Cushing's syndrome. In support of a program to develop agents superior to mitotane, it is the purpose of this study to explore the relationship of the metabolism of mitotane to its binding to adrenal cortex tissue from several sources. The objective was to detect the mitotane moiety responsible for its covalent binding in various… Expand
Adrenal proteins bound by a reactive intermediate of mitotane
Pharmacokinetics of the adrenocorticolytic compounds 3-methylsulphonyl-DDE and o,p′-DDD (mitotane) in Minipigs
Chiral effects in adrenocorticolytic action of o,p′-DDD (mitotane) in human adrenal cells
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