Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes.

@article{Clemmons2012MetabolicAO,
  title={Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes.},
  author={David Robert Clemmons},
  journal={Endocrinology and metabolism clinics of North America},
  year={2012},
  volume={41 2},
  pages={
          425-43, vii-viii
        }
}
Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates free fatty acid use. The administration of IGF-I to patients with extreme insulin resistance results in improvement in glycemic control, and IGF-I is associated with lowering glucose and enhancing insulin sensitivity in Type 1 and Type 2 diabetes. However, patients with diabetes are also sensitive to… CONTINUE READING
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