Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.


OBJECTIVE Carbonic anhydrase (CA) inhibitors topiramate and zonisamide can induce metabolic acidosis in some patients. Our aims were to assess the prevalence and severity of this acidosis and to determine its predictors. METHODS For 70 patients established on treatment with topiramate (n=55) or zonisamide (n=14) or both (n=1), we measured electrolytes… (More)
DOI: 10.1097/FPC.0b013e3283441b95


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