Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.

@article{May1986MetabolicAS,
  title={Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.},
  author={Ron Crews May and Ralph A. Kelly and William E. Mitch},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 2},
  pages={614-21}
}
Metabolic acidosis is associated with enhanced renal ammonia-genesis which is regulated, in part, by glucocorticoids. The interaction between glucocorticoids and chronic metabolic acidosis on nitrogen utilization and muscle protein metabolism is unknown. In rats pair-fed by gavage, we found that chronic acidosis stunted growth and caused a 43% increase in urinary nitrogen and an 87% increase in urinary corticosterone. Net protein degradation in incubated epitrochlearis muscles from chronically… CONTINUE READING
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