Metabolic acidosis increases fibroblast growth factor 23 in neonatal mouse bone.

@article{Krieger2012MetabolicAI,
  title={Metabolic acidosis increases fibroblast growth factor 23 in neonatal mouse bone.},
  author={Nancy S. Krieger and Christopher D. Culbertson and Kelly Kyker-Snowman and David A. Bushinsky},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 3},
  pages={F431-6}
}
Fibroblast growth factor 23 (FGF23) significantly increases with declining renal function, leading to reduced renal tubular phosphate reabsorption, decreased 1,25-dihydroxyvitamin D, and increased left ventricular hypertrophy. Elevated FGF23 is associated with increased mortality. FGF23 is synthesized in osteoblasts and osteocytes; however, the mechanisms by which it is regulated are not clear. Patients with chronic kidney disease have decreased renal acid excretion leading to metabolic… CONTINUE READING
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