Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function.

@article{Lucioni2002MetabolicAI,
  title={Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function.},
  author={Alvaro Lucioni and Christopher Womack and Mark W Musch and F. R. de la Rocha and Cres Bookstein and Eugene B Chang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 1},
  pages={
          G51-6
        }
}
Chronic metabolic acidosis increases intestinal Na absorption, although through undefined mechanisms. Whether this occurs through enhanced expression and/or function of the brush-border Na+/H+ exchangers (NHE)2 and NHE3 is unknown. Metabolic acidosis was induced in rats by feeding ammonium chloride through their drinking water. Intestinal NHE activities were measured using brush-border 22Na+ uptake. Western and Northern blots measured changes in protein and mRNA expression, respectively… CONTINUE READING

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