Metabolic acidosis and the importance of balanced equations
@article{Lane2008MetabolicAA, title={Metabolic acidosis and the importance of balanced equations}, author={Andrew N. Lane and Teresa W.-M. Fan and Richard M. Higashi}, journal={Metabolomics}, year={2008}, volume={5}, pages={163-165} }
Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks…
31 Citations
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The classic view that most of the net proton efflux from C6 gliomas originates in glycolytic formation of lactate and H+ inside the tumor is supported, but add that some lactate is taken up into cells in the rim on MCT1, and some lactates diffuses away, leaving its associated protons available to re-enter cells for extrusion on NHE1.
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The in vivo results support a multipronged approach to tumor treatment based on minimizing intracellular pH by targeting several proton production and proton transport processes, among which the very efficient MCT4 proton/lactate co‐transport deserves particular attention.
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