Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance

@article{Cohen2013MetabolicTO,
  title={Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance},
  author={Laurie D. Cohen and Rina Zuchman and Oksana Sorokina and Anke M{\"u}ller and D. Dieterich and J. Armstrong and T. Ziv and N. Ziv},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Chemical synapses contain multitudes of proteins, which in common with all proteins, have finite lifetimes and therefore need to be continuously replaced. Given the huge numbers of synaptic connections typical neurons form, the demand to maintain the protein contents of these connections might be expected to place considerable metabolic demands on each neuron. Moreover, synaptic proteostasis might differ according to distance from global protein synthesis sites, the availability of distributed… Expand
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