Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus

@article{Boney2005MetabolicSI,
  title={Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus},
  author={Charlotte M. Boney and Anila. Verma and Richard J Tucker and Betty R. Vohr},
  journal={Pediatrics},
  year={2005},
  volume={115},
  pages={e290 - e296}
}
Objective. Childhood obesity has contributed to an increased incidence of type 2 diabetes mellitus and metabolic syndrome (MS) among children. Intrauterine exposure to diabetes and size at birth are risk factors for type 2 diabetes mellitus, but their association with MS in childhood has not been demonstrated. We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children. Study Design. The major components of MS (obesity, hypertension… 

Paper Mentions

Interventional Clinical Trial
The goal of this study is to compare two different thresholds for initiation of medical treatment for GDM. Pregnant women diagnosed with GDM will be randomized to either start… 
ConditionsGestational Diabetes
InterventionDrug
Interventional Clinical Trial
Studies evaluating lifestyle intervention in obese women during pregnancy have reported limited success in decreasing excessive gestational weight gain, and have failed to achieve… 
ConditionsLifestyle-related Condition, Macrosomia, Fetal, Obesity
InterventionBehavioral
Interventional Clinical Trial
Gestational diabetes (GDM) is a condition of carbohydrate intolerance with onset or first recognition in pregnancy. The prevalence of GDM is as high as 25% in some populations and… 
ConditionsGestational Diabetes
InterventionDevice
Observational Clinical Trial
The objective of this study is to determine the most appropriate and effective approach for the diagnosis of gestational diabetes mellitus (GDM) among pregnant women receiving focused… 
ConditionsDiabetes, Gestational
InterventionProcedure
Gestational diabetes: The forerunner for the development of maternal and childhood obesity and metabolic syndrome?
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TLDR
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OBJECTIVE: To estimate whether children aged 2–4 years of mothers with gestational diabetes are at increased risk for childhood obesity. Secondary objectives included examining the associations
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TLDR
Adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes are risk groups for overweight and the metabolic syndrome.
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TLDR
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Obesity and gestational diabetes in pregnant care and clinical practice.
TLDR
The best management of obesity and Gestational Diabetes Mellitus includes pre-conception planning to reduce the risks during pregnancy and improve the quality of life of these patients.
Association between maternal diabetes, being large for gestational age and breast-feeding on being overweight or obese in childhood
TLDR
LGA is a stronger marker for risk of being overweight/obese in early childhood, compared with maternal diabetes during pregnancy; however, this association was not maintained in LGA children of mothers with diabetes.
Maternal obesity, diabetes mellitus and cord blood biomarkers in large-for-gestational age infants.
TLDR
Investigation of factors associated with LGA status and their relationship to inflammatory biomarkers found only RANTES, a chemokine secreted by white adipose tissue, was significantly increased in LGA infants, and this association remained essentially unchanged after adjustment for maternal DM and BMI.
Association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus.
TLDR
Pre-pregnancy BMI, HDL-C and birth weight of a large child born previously are the independent predictors for LGA, but results of glucose levels during OGTT are not useful in the prediction of LGA in GDM pregnancies.
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