Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

  title={Metabolic Signatures of Insulin Resistance in 7,098 Young Adults},
  author={Peter W{\"u}rtz and Ville-Petteri M{\"a}kinen and Pasi Soininen and Antti J. Kangas and Taru Tukiainen and Johannes Kettunen and Markku J. Savolainen and Tuija H Tammelin and Jorma S. A. Viikari and Tapani R{\"o}nnemaa and Mika A. P. K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Samuli Ripatti and Olli T. Raitakari and Marjo-Riitta J{\"a}rvelin and Mika Ala-Korpela},
Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31 ± 3 years; 52% women) to elucidate underlying metabolic pathways. Insulin resistance was assessed by the homeostasis model (HOMA-IR) and circulating metabolites quantified by high-throughput nuclear magnetic resonance spectroscopy in two population-based cohorts. Associations were analyzed using regression models adjusted for age, waist, and standard lipids. Branched-chain and aromatic amino acids… CONTINUE READING
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