Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.

@article{Kang2015MetabolicRB,
  title={Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.},
  author={H. Kang and Jun Fan and Ruiting Lin and Shannon E. Elf and Quanjiang Ji and Liang Zhao and Lingtao Jin and Jae Ho Seo and Changliang Shan and Jack L. Arbiser and Cynthia K Cohen and Daniel J. Brat and Henry M. Miziorko and Eunhee Kim and Omar Abdel-Wahab and Taha Merghoub and Stefan Fr{\"o}hling and Claudia Scholl and Pablo Tamayo and David Allen Barbie and Lu Zhou and Brian P. Pollack and Kevin E Fisher and Ragini Reiney Kudchadkar and David H. Lawson and Gabriel L. Sica and Michael R. Rossi and Sagar Lonial and Hanna J Khoury and Fadlo R. Khuri and Benjamin Hoyoung Lee and Titus J Boggon and Chuan He and Sumin Kang and Jing Chen},
  journal={Molecular cell},
  year={2015},
  volume={59 3},
  pages={
          345-358
        }
}
Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a "synthetic lethal" interaction between oncogenic BRAF V600E and a ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL). HMGCL… CONTINUE READING