Metabolic Regulation of Cellular Plasticity in the Pancreas

@article{Ninov2013MetabolicRO,
  title={Metabolic Regulation of Cellular Plasticity in the Pancreas},
  author={Nikolay Ninov and Daniel Hesselson and Philipp Gut and Amy Zhou and Kevin Fidelin and Didier Y R Stainier},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={1242-1250}
}
Obese individuals exhibit an increase in pancreatic β cell mass; conversely, scarce nutrition during pregnancy has been linked to β cell insufficiency in the offspring [reviewed in 1, 2]. These phenomena are thought to be mediated mainly through effects on β cell proliferation, given that a nutrient-sensitive β cell progenitor population in the pancreas has not been identified. Here, we employed the fluorescent ubiquitination-based cell-cycle indicator system to investigate β cell replication… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies.

  • Current topics in developmental biology
  • 2017
VIEW 15 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Zebrafish as a Model for Obesity and Diabetes

  • Front. Cell Dev. Biol.
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Similar Papers

Loading similar papers…