Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma

  title={Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma},
  author={Llewellyn Jalbert and Adam Elkhaled and Joanna J Phillips and Evan Neill and Aurelia Williams and Jason C. Crane and Marram P. Olson and Annette M. Molinaro and Mitchel S. Berger and John Kurhanewicz and Sabrina M. Ronen and Susan M. Chang and Sarah J. Nelson},
  booktitle={Scientific reports},
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. Because of their relatively long overall median survival, more aggressive treatments are typically reserved for patients that have undergone… CONTINUE READING
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the emergence of genetic information

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