Metabolic Phenotyping in Health and Disease
@article{Holmes2008MetabolicPI, title={Metabolic Phenotyping in Health and Disease}, author={E. Holmes and I. D. Wilson and J. Nicholson}, journal={Cell}, year={2008}, volume={134}, pages={714-717} }
Analyzing metabolites (small molecules <1 kDa) in body fluids such as urine and plasma using various spectroscopic methods provides information on the metabotype (metabolic phenotype) of individuals or populations, information that can be applied to personalized medicine or public healthcare.
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References
SHOWING 1-10 OF 33 REFERENCES
Human metabolic phenotype diversity and its association with diet and blood pressure
- Biology, Medicine
- Nature
- 2008
- 856
- PDF
Metabonomics: a platform for studying drug toxicity and gene function
- Biology, Medicine
- Nature Reviews Drug Discovery
- 2002
- 1,632
- PDF
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
- Biology, Medicine
- Nature Genetics
- 2007
- 144
Global systems biology, personalized medicine and molecular epidemiology
- Biology, Medicine
- Molecular systems biology
- 2006
- 337
- PDF
Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population
- Biology, Medicine
- Diabetes
- 2008
- 232
- Highly Influential
- PDF
Symbiotic gut microbes modulate human metabolic phenotypes
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2008
- 876
- PDF
Human disease classification in the postgenomic era: A complex systems approach to human pathobiology
- Biology, Medicine
- Molecular systems biology
- 2007
- 513
- PDF