Metabolic Network Topology Reveals Transcriptional Regulatory Signatures of Type 2 Diabetes

@inproceedings{Zelezniak2010MetabolicNT,
  title={Metabolic Network Topology Reveals Transcriptional Regulatory Signatures of Type 2 Diabetes},
  author={Aleksej Zelezniak and Tune H. Pers and Sim{\~a}o Soares and Mary Elizabeth Patti and Kiran Raosaheb Patil},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Type 2 diabetes mellitus (T2DM) is a disorder characterized by both insulin resistance and impaired insulin secretion. Recent transcriptomics studies related to T2DM have revealed changes in expression of a large number of metabolic genes in a variety of tissues. Identification of the molecular mechanisms underlying these transcriptional changes and their impact on the cellular metabolic phenotype is a challenging task due to the complexity of transcriptional regulation and the highly… CONTINUE READING