Metabolic Modulation of Glioblastoma with Dichloroacetate

@article{Michelakis2010MetabolicMO,
  title={Metabolic Modulation of Glioblastoma with Dichloroacetate},
  author={Evangelos D. Michelakis and Gopinath Sutendra and Peter Dromparis and L. Webster and Alois Haromy and Erin Niven and Cm Maguire and Terri-Lynn Gammer and John R. Mackey and Dorcus Fulton and Bassam Abdulkarim and Michael S Mcmurtry and Kenneth C. Petruk},
  journal={Science Translational Medicine},
  year={2010},
  volume={2},
  pages={31ra34 - 31ra34}
}
Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, shifts metabolism away from aerobic glycolysis in glioblastoma tumor cells and may have clinical efficacy in patients. Metabolic Modulators in Cancer Cancer cells are optimized for growth, not performance. Their metabolism is geared to provide the raw materials needed for new cells, and that package includes resistance to apoptosis and mitochondria that run on aerobic glycolysis, not oxidative phosphorylation. In a small study… 
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