Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

@article{Muoio2014MetabolicIW,
  title={Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock},
  author={Deborah M. Muoio},
  journal={Cell},
  year={2014},
  volume={159},
  pages={1253-1262}
}
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by an intricate network of metabolic and cell signaling events that enable exquisite crosstalk and cooperation between competing substrates to maintain energy and glucose homeostasis. By… CONTINUE READING

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