Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.

@article{Gomes2016MetabolicII,
  title={Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.},
  author={Ana Lucia Luiza Gomes and Ana Garzaran Teijeiro and Stefan Bur{\'e}n and Krishna Seshu Tummala and Mahmut Yilmaz and Ari Waisman and J. P. Theurillat and Cristian Perna and Nabil Djouder},
  journal={Cancer cell},
  year={2016},
  volume={30 1},
  pages={
          161-175
        }
}
Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymphocytes and interleukin 17A (IL-17A). This induces white adipose tissue neutrophil infiltration mediating insulin resistance (IR) and fatty acid release… CONTINUE READING
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