Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

  title={Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment},
  author={Kathrin Renner and Katrin Singer and Gudrun E. Koehl and Edward Kenneth Geissler and Katrin Peter and Peter J Siska and Marina P. Kreutz},
  booktitle={Front. Immunol.},
Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor cells and the number and activity of tumor-infiltrating T cells represent a good marker for tumor prognosis. Based on these findings, immunotherapy, e.g., checkpoint blockade, has received considerable attention during the last couple of years. However, for the majority of patients, immune control of their tumors is gray theory as malignant cells use effective mechanisms to outsmart the immune system… CONTINUE READING
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