Metabolic Generation and Utilization of Phosphate Bond Energy

@inproceedings{Lipmann2006MetabolicGA,
  title={Metabolic Generation and Utilization of Phosphate Bond Energy},
  author={Fritz Albert Lipmann},
  year={2006}
}
of inorganic phosphate. The machine-like functioning of the revolving sequence of reactions appears from the schematic representation shown in Fig. 1. For the undisturbed maintenance of this complicated series of reactions a well-balanced equilibrium is needed between the great number of enzymatic reactions involved. Oxido-reductive formation of ~ p h and its removal by adenylic acid must follow each other in due course, in order to 
View via Publisher
web.archive.org
186 Citations
Highly Influential Citations
4
Background Citations
76
Methods Citations
1

Figures from this paper

186 Citations

Introduction to Metabolism

Metabolism is defined as the sum total of all reactions that occur in the cell. It consists of two phases: catabolism and anabolism. Catabolism is the degradation of complex molecules to simpler ones…

Energy Conservation via Electron-Transferring Flavoprotein in Anaerobic Bacteria

Energy conservation in chemotrophic organisms is generally coupled to redox reactions in catabolic pathways. In the oxidative part or branch, “energy-rich” compounds are formed, from which ATP is…

Quantifying the energetics of metabolic reactions in diverse biogeochemical systems: electron flow and ATP synthesis

Classical solution chemistry and thermodynamics have been used to quantify the energetics of two fundamental bioenergetic processes over a range of environmental conditions in which life is known to…

How Prebiotic Chemistry and Early Life Chose Phosphate

This review is aimed at demonstrating that considering mixed anhydrides or other species more reactive than esters and anHydrides can help in solving the paradox about early stages of life.

Biocatalytic Phosphorylations of Metabolites: Past, Present, and Future.

From crossbridges to metabolism: system biology for energetics.

  • M. Kushmerick
  • Biology
    Advances in experimental medicine and biology
  • 2005
It is argued that the stoichiometric inter-relationships, defined by chemical rules, offer bases from which strong inferences can be made to integrate mechanisms as diverse as molecular crossbridge motors, metabolic fluxes generating ATP, cell respiration, and muscle oxygen consumption.

Hydrolytic Proteins of Sugarcane: The Acid Phosphatases

Although phosphatase activity was known in rice, yeast, and numerous animal tissues almost 60 years ago, its physiological necessity was first demonstrated by Robison and Soames in 1924 and is now known to be essential for the metabolism of carbohydrates, nucleotides, and phospholipids, and for the process of muscular contraction.

Phosphorylation and acylation transfer reactions: Clues to a dual origin of metabolism

Early bioenergetic evolution

This paper outlines an energetically feasible path from a particular inorganic setting for the origin of life to the first free-living cells, and focuses on the main evolutionary transitions in early bioenergetic evolution.

A Novel Mathematical Equation For Calculating The Number of ATP Molecules Generated From Sugars In Cells

A novel method to calculate the number of ATP molecules generated from the consumption of any sugar (having 3-7 carbons) based on the oxidation states of the sugar’s carbons is described.
...

References

SHOWING 1-10 OF 100 REFERENCES

Biochemistry: Coupling between Pyruvic Acid Dehydrogenation and Adenylic Acid Phosphorylation

A NEW coupling of oxidoreduction and phosphorylation, with thiamin (vitamin B1) pyrophosphate as a link of the reaction chain, was found with dry preparations of Bacterium Delbrückii (Acidificans…

Acetylphosphate and Pyruvate Oxidation

LIPMANN has recently reported1 that adenylic acid is partially phosphorylated to adenosino polyphos-phate by preparations of Bacterium Delbrückii in the presence of acetylphosphate, and suggested…

The coupling of oxido-reductions and dismutations with esterification of phosphate in muscle.

It is shown that in a dialysed muscle extract glycogen can react with inorganic phosphate giving hexosemonophosphate, and if adenylpyrophosphate is now added, hexosediphosphates are formed.

The oxidation-reduction potential of coenzyme I

‘Coupling’ of Phosphorylation with Oxidation of Pyruvic Acid in Brain Tissue

Observations suggested that a cycle of phosphorylation is involved in the enzymatic oxidation of pyruvate.

Formation and breakdown of glycogen in the liver.

It is shown that autolysed rabbit muscle extract forms from glycogen and phosphate a difficultly hydrolysable hexosemonophosphate -which Ostern et al.

Flavin Component of the Pyruvic Acid Oxidation System

EVIDENCE for the earlier suggested1 participation of a flavin compound in pyruvic acid oxidation by Bacterium Delbrückii has been obtained by a procedure similar to that used by Warburg and…

The relationship of bacterial utilization of CO(2) to succinic acid formation.

Results show that in the dissimilation of either glucose or glycerol, inhibition of C02 utilization causes an approximately equimolar reduction in the formation of succinic acid.

Role of Phosphate in Pyruvic Acid Dehydrogenation

DURING earlier work1 on the problem of pyruvic acid dehydrogenation with Bacterium acidificans longissimum (Delbrückii), it was found that in the absence of inorganic phosphate no reaction took…

Phosphate in tumours and muscle

  • W. Franks
  • Biology
    The Journal of physiology
  • 1932
There is certain indirect evidence in favour of phosphate intermediaries in surviving tumour glycolysis, and the residue from Jensen's rat sarcoma formed some free phosphate and methyl glyoxal from magnesium hexosediphosphate.
...