Metabolic Gene Polymorphisms and Risk of Dysmenorrhea

@article{Wu2000MetabolicGP,
  title={Metabolic Gene Polymorphisms and Risk of Dysmenorrhea},
  author={Di Wu and Xiaobin Wang and Dafang Chen and Tianhua Niu and Jiatong Ni and Xue Liu and Xiping Xu},
  journal={Epidemiology},
  year={2000},
  volume={11},
  pages={648-653}
}
We conducted a molecular epidemiologic study in rural China to investigate the association of the cytochrome P450 2D6 (CYP2D6) and glutathione S-transferase Mu (GSTM1) polymorphisms with dysmenorrhea. This report includes 435 subjects, 129 with and 306 without any history of dysmenorrhea, who did not smoke or drink alcohol. We obtained information on dysmenorrhea and major covariates by questionnaire interview. We used categorical methods and logistic regression models to evaluate the… 
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YP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea.
Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea.
MTHFR and IL-4 Gene Polymorphisms Are Not Associated with Primary Dysmenorrhea in Young Adults
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According to the findings of first study of intron 3 VNTR polymorphism in the IL-4 gene and C677T polymorphisms in MTHFR gene, these polymorphisms do not lead to increased susceptibility to primary dysmenorrhea.
The prevalence and risk factors of dysmenorrhea.
TLDR
It is confirmed that dys menorrhea improves with increased age, parity, and use of oral contraceptives and is positively associated with stress and family history of dysmenorrhea.
Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents.
TLDR
The results suggest that ESR1 gene polymorphisms may be associated with dysmenorrhea.
Combined Genotype Analysis of GSTM1 and GSTT1 Polymorphisms in a Polish Population
TLDR
Significant differences occurred between men and women in some age groups, which could suggest that sex differences in susceptibility to diseases may be caused by genotype differences in detoxifying enzymes such as glutathione S-transferase.
Characteristics and Determinants of Primary Dysmenorrhea in Young Adults
TLDR
Dysmenorrhea is becoming a highly debilitating event among young adult females with a n increasing prevalence rate, and the notorious determining factor may be the family history baring significant association to dys menorrhea.
FAMILIAL PREDISPOSITION OF DYSMENORRHEA AMONG THE MEDICAL STUDENTS
TLDR
It is suggested that genetic factor is involved in the pathogenesis of primary dysmenorrhea and increases the familial tendency, therefore positive family history could be the strong predictor for occurrence of dys menorrhea in offspring and in siblings.
Risk factors for dysmenorrhea among young adult female university students.
TLDR
The results suggest that earlier age at menarche, longer duration of menstrual flow, prior family history of dysmenorrhea and smoking at least one cigarette a day are important risk factors associated with dys menorrhea.
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