Metabolic Gene Polymorphisms and Risk of Dysmenorrhea

  title={Metabolic Gene Polymorphisms and Risk of Dysmenorrhea},
  author={Di Wu and Xiaobin Wang and Dafang Chen and Tianhua Niu and Jiatong Ni and Xue Liu and Xiping Xu},
We conducted a molecular epidemiologic study in rural China to investigate the association of the cytochrome P450 2D6 (CYP2D6) and glutathione S-transferase Mu (GSTM1) polymorphisms with dysmenorrhea. This report includes 435 subjects, 129 with and 306 without any history of dysmenorrhea, who did not smoke or drink alcohol. We obtained information on dysmenorrhea and major covariates by questionnaire interview. We used categorical methods and logistic regression models to evaluate the… 
Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea
YP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea.
Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea.
MTHFR and IL-4 Gene Polymorphisms Are Not Associated with Primary Dysmenorrhea in Young Adults
According to the findings of first study of intron 3 VNTR polymorphism in the IL-4 gene and C677T polymorphisms in MTHFR gene, these polymorphisms do not lead to increased susceptibility to primary dysmenorrhea.
The prevalence and risk factors of dysmenorrhea.
It is confirmed that dys menorrhea improves with increased age, parity, and use of oral contraceptives and is positively associated with stress and family history of dysmenorrhea.
Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents.
The results suggest that ESR1 gene polymorphisms may be associated with dysmenorrhea.
Combined Genotype Analysis of GSTM1 and GSTT1 Polymorphisms in a Polish Population
Significant differences occurred between men and women in some age groups, which could suggest that sex differences in susceptibility to diseases may be caused by genotype differences in detoxifying enzymes such as glutathione S-transferase.
Characteristics and Determinants of Primary Dysmenorrhea in Young Adults
Dysmenorrhea is becoming a highly debilitating event among young adult females with a n increasing prevalence rate, and the notorious determining factor may be the family history baring significant association to dys menorrhea.
It is suggested that genetic factor is involved in the pathogenesis of primary dysmenorrhea and increases the familial tendency, therefore positive family history could be the strong predictor for occurrence of dys menorrhea in offspring and in siblings.
Risk factors for dysmenorrhea among young adult female university students.
The results suggest that earlier age at menarche, longer duration of menstrual flow, prior family history of dysmenorrhea and smoking at least one cigarette a day are important risk factors associated with dys menorrhea.


Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion.
The data provide little evidence of an association between GSTM1 or NAT2 genotype and risk of spontaneous abortion, and an inverse association is found in an independent case-control study from New York involving 89 cases.
Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction.
Evidence of gene-environment interaction is provided and support of the role of genetic susceptibility in the evaluation of reproductive toxins is supported, supported by further assessment of the roles of CYP1A1 and GSTT1.
Cigarette smoking, alcohol consumption, and risk of primary dysmenorrhea.
We analyzed the relation between cigarette smoking, alcohol consumption, and risk of dysmenorrhea using data from a case-control study in Milan, Italy. With never-smokers as the reference category,
Microsomal Epoxide Hydrolase Polymorphism and Risk of Spontaneous Abortion
The findings persisted after adjustment for age, education, parity, smoking, alcohol use, occupation, and pesticide exposure, as well as in subgroup analysis, indicating that the two variants have opposite associations with spontaneous abortion.
Factors influencing the prevalence and severity of dysmenorrhoea in young women
The severity of dysmenorrhoea was significantly associated with the duration of menstrual flow, menarcheal age and cigarette smoking, and was not associated with age as an isolated factor, nor with height, weight, length of menstrual cycle or frequency of physical exercise.
PRIMARY dysmenorrhea.
  • O. Ra
  • Medicine
    Research in the service of medicine
  • 1945
Increased oxidative stress and decreased antioxidants as one of the important contributing factor in the pathogenesis of primary dysmenorrhea is revealed.
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
A solid basis is provided for prediction of CYP2D6 capacity, as required in drug research and routine drug treatment, and significant differences in enzymatic activity measured by the dextromethorphan metabolic ratio (MR) are shown.
An epidemiologic study of young women with dysmenorrhea.
Vegetable consumption and risk of chronic disease
Data from the 1993 Italian Household Multipurpose Survey was used to analyze the relation between frequency of vegetable consumption and prevalence of 12 chronic diseases and observed little association with diabetes mellitus, hypertension, and allergy.