Metabolic Flux Estimation from Incomplete Labelling Measurements Using the Expectation/Conditional-Maximisation Algorithm

Abstract

In this work, the problem of metabolic flux estimation is formulated as a problem of parameter estimation from incomplete labelling data. The expectation/conditional maximisation (ECM) algorithm is used to determined a maximum-likelihood (ML) estimate because of its simplicity and stable convergence. We propose to simplify a nonlinear inverse problem… (More)

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