Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods

@article{GarcaMuoz2014MetabolicFO,
  title={Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods},
  author={Cristina Garc{\'i}a-Mu{\~n}oz and Fabrice Vaillant},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2014},
  volume={54},
  pages={1584 - 1598}
}
Consumption of dietary ellagitannins (ETs) has been associated with different health benefits. Nonetheless, ETs are not bioavailable as such and are metabolized in vivo. They are partially converted into ellagic acid (EA) in the upper gastrointestinal (GI) tract, but this first metabolite is also poorly bioavailable. In the lower GI tract, EA and residual ETs are metabolized by gut microbiota to produce urolithins, which, together with their conjugate relatives, persist at relatively high… 

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References

SHOWING 1-10 OF 111 REFERENCES

Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.

The whole metabolism of ETs is shown for the first time, confirming previous studies in humans and explaining the long persistency of urolithin metabolites in the body mediated by an active enterohepatic circulation.

Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling.

The effects of UA, EA, and ET-rich fruit extracts on Wnt signaling in a human 293T cell line were investigated using a luciferase reporter of canonical Wnt pathway-mediated transcriptional activation, suggesting that ET- rich foods have potential against colon carcinogenesis and that urolithins are relevant bioactive constituents in the colon.

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice.

The results suggest that urolithin glucuronides and dimethyl ellagic acid may be the molecules responsible for the beneficial effects of PJ against PCa.

Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay.

Results showed that the antioxidant activity of urolithins was correlated with the number of hydroxy groups as well as the lipophilicity of the molecule.

Ellagitannins : nature, occurrence and dietary burden

It seems unlikely that normal consumption of ellagitannins can cause toxic effects in man, but any attempt to increase the intake significantly in pursuit of the suggested benefits should be resisted until the metabolism and pharmacokinetics are better understood.

Gastrointestinal microflora, food components and colon cancer prevention.

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice.

Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability.

Results indicate that urolithin B (a previously described antiangiogenic and hyaluronidase inhibitor compound) is a biomarker of human exposure to dietary ETs and may be useful in intervention studies with ET-containing products.
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