Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

  title={Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins},
  author={Alfredo Castello and Matthias W. Hentze and Thomas Preiss},
  journal={Trends in Endocrinology & Metabolism},
In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignant transformation are now known to involve 'metabolic remodeling' with profound changes in the expression of many metabolic enzyme genes. This review focuses on the recent identification of RNA-binding activity of numerous metabolic enzymes. We… CONTINUE READING
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