Metabolic Engineering of Pseudomonas putida KT2440 to Produce Anthranilate from Glucose

@article{Kuepper2015MetabolicEO,
  title={Metabolic Engineering of Pseudomonas putida KT2440 to Produce Anthranilate from Glucose},
  author={J. Kuepper and Jasmin Dickler and Michael Biggel and S. Behnken and G. Jaeger and N. Wierckx and L. Blank},
  journal={Frontiers in Microbiology},
  year={2015},
  volume={6}
}
  • J. Kuepper, Jasmin Dickler, +4 authors L. Blank
  • Published 2015
  • Biology, Medicine
  • Frontiers in Microbiology
  • The Pseudomonas putida KT2440 strain was engineered in order to produce anthranilate (oAB, ortho-aminobenzoate), a precursor of the aromatic amino acid tryptophan, from glucose as sole carbon source. To enable the production of the metabolic intermediate oAB, the trpDC operon encoding an anthranilate phosphoribosyltransferase (TrpD) and an indole-3-glycerol phosphate synthase (TrpC), were deleted. In addition, the chorismate mutase (pheA) responsible for the conversion of chorismate over… CONTINUE READING
    31 Citations
    Metabolic Engineering of Pseudomonas putida KT2440 for the Production of para-Hydroxy Benzoic Acid
    • 26
    • PDF
    High-Yield Production of 4-Hydroxybenzoate From Glucose or Glycerol by an Engineered Pseudomonas taiwanensis VLB120
    • 12
    • PDF

    References

    SHOWING 1-10 OF 90 REFERENCES
    Metabolic engineering for improving anthranilate synthesis from glucose in Escherichia coli
    • 72
    • Highly Influential
    Engineering of Solvent-Tolerant Pseudomonas putida S12 for Bioproduction of Phenol from Glucose
    • 178
    • PDF
    Optimization of the solvent-tolerant Pseudomonas putida S12 as host for the production of p-coumarate from glucose
    • 78
    The solvent-tolerant Pseudomonas putida S12 as host for the production of cinnamic acid from glucose
    • 100
    Functional analysis of aromatic biosynthetic pathways in Pseudomonas putida KT2440
    • 15
    The Entner-Doudoroff pathway empowers Pseudomonas putida KT2440 with a high tolerance to oxidative stress.
    • 130
    Characterization and regulation of anthranilate synthetase from a chloramphenicol-producing streptomycete.
    • 17
    • PDF