Metabolic Engineering of Pseudomonas putida KT2440 to Produce Anthranilate from Glucose

@article{Kuepper2015MetabolicEO,
  title={Metabolic Engineering of Pseudomonas putida KT2440 to Produce Anthranilate from Glucose},
  author={J. Kuepper and Jasmin Dickler and Michael Biggel and S. Behnken and G. Jaeger and N. Wierckx and L. Blank},
  journal={Frontiers in Microbiology},
  year={2015},
  volume={6}
}
  • J. Kuepper, Jasmin Dickler, +4 authors L. Blank
  • Published 2015
  • Biology, Medicine
  • Frontiers in Microbiology
    • The Pseudomonas putida KT2440 strain was engineered in order to produce anthranilate (oAB, ortho-aminobenzoate), a precursor of the aromatic amino acid tryptophan, from glucose as sole carbon source. To enable the production of the metabolic intermediate oAB, the trpDC operon encoding an anthranilate phosphoribosyltransferase (TrpD) and an indole-3-glycerol phosphate synthase (TrpC), were deleted. In addition, the chorismate mutase (pheA) responsible for the conversion of chorismate over… CONTINUE READING
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    31 Citations
    Background Citations
    9
    Methods Citations
    1
    31 Citations
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