Metabolic Effects of Cholecystectomy: Gallbladder Ablation Increases Basal Metabolic Rate through G-Protein Coupled Bile Acid Receptor Gpbar1-Dependent Mechanisms in Mice

@inproceedings{Corts2015MetabolicEO,
  title={Metabolic Effects of Cholecystectomy: Gallbladder Ablation Increases Basal Metabolic Rate through G-Protein Coupled Bile Acid Receptor Gpbar1-Dependent Mechanisms in Mice},
  author={V{\'i}ctor Cort{\'e}s and L Pi{\~n}eiro Amigo and Silvana Zanlungo and Jos{\'e} Galgani and Ferm{\'i}n A. Robledo and Marco Arrese and Francisco Bozinovic and Flavio Nervi},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND & AIMS Bile acids (BAs) regulate energy expenditure by activating G-protein Coupled Bile Acid Receptor Gpbar1/TGR5 by cAMP-dependent mechanisms. Cholecystectomy (XGB) increases BAs recirculation rates resulting in increased tissue exposure to BAs during the light phase of the diurnal cycle in mice. We aimed to determine: 1) the effects of XGB on basal metabolic rate (BMR) and 2) the roles of TGR5 on XGB-dependent changes in BMR. METHODS BMR was determined by indirect calorimetry in… CONTINUE READING
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