Metabolic Depletion of Atp by Fructose Inversely Controls Cd95- and Tumor Necrosis Factor Receptor 1–Mediated Hepatic Apoptosis

@article{Latta2000MetabolicDO,
  title={Metabolic Depletion of Atp by Fructose Inversely Controls Cd95- and Tumor Necrosis Factor Receptor 1–Mediated Hepatic Apoptosis},
  author={Markus Latta and Gerald K{\"u}nstle and Marcel Leist and Albrecht Wendel},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={1975 - 1986}
}
Hepatocyte apoptosis is crucial in several forms of liver disease. Here, we examined in different models of murine liver injury whether and how metabolically induced alterations of hepatocyte ATP levels control receptor-mediated apoptosis. ATP was depleted either in primary hepatocytes or in vivo by various phosphate-trapping carbohydrates such as fructose… CONTINUE READING