Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways

@article{MorenoSnchez2008MetabolicCA,
  title={Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways},
  author={Rafael Moreno-S{\'a}nchez and Emma Saavedra and Sara Rodr{\'i}guez-Enr{\'i}quez and Viridiana Ol{\'i}n-Sandoval},
  journal={Journal of Biomedicine and Biotechnology},
  year={2008},
  volume={2008},
  pages={379 - 385}
}
The traditional experimental approaches used for changing the flux or the concentration of a particular metabolite of a metabolic pathway have been mostly based on the inhibition or over-expression of the presumed rate-limiting step. However, the attempts to manipulate a metabolic pathway by following such approach have proved to be unsuccessful. Metabolic Control Analysis (MCA) establishes how to determine, quantitatively, the degree of control that a given enzyme exerts on flux and on the… CONTINUE READING
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Understanding the Control of Metabolism

  • D. Fell
  • 1997
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