Metabolic Changes in Skin Caused by Scd1 Deficiency: A Focus on Retinol Metabolism

@inproceedings{Flowers2011MetabolicCI,
  title={Metabolic Changes in Skin Caused by Scd1 Deficiency: A Focus on Retinol Metabolism},
  author={Matthew T. Flowers and Chad M. Paton and Sheila M. O'Byrne and Kevin J. Schiesser and John A. Dawson and William S. Blaner and Christina Kendziorski and James M Ntambi},
  booktitle={PloS one},
  year={2011}
}
We previously reported that mice with skin-specific deletion of stearoyl-CoA desaturase-1 (Scd1) recapitulated the skin phenotype and hypermetabolism observed in mice with a whole-body deletion of Scd1. In this study, we first performed a diet-induced obesity experiment at thermoneutral temperature (33°C) and found that skin-specific Scd1 knockout (SKO) mice still remain resistant to obesity. To elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin… CONTINUE READING

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