Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications.

  title={Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications.},
  author={Gang Wu and Qiang Yan and J Andrew Jones and Yinjie J. Tang and Stephen S. Fong and Mattheos A. G. Koffas},
  journal={Trends in biotechnology},
  volume={34 8},
Engineering cell metabolism for bioproduction not only consumes building blocks and energy molecules (e.g., ATP) but also triggers energetic inefficiency inside the cell. The metabolic burdens on microbial workhorses lead to undesirable physiological changes, placing hidden constraints on host productivity. We discuss cell physiological responses to metabolic burdens, as well as strategies to identify and resolve the carbon and energy burden problems, including metabolic balancing, enhancing… CONTINUE READING
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