Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

@inproceedings{Carvalho2012MetabolicAI,
  title={Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities},
  author={Cristina Isabel Carvalho and Susana M Cardoso and S{\'o}nia Catarina Correia and Renato Xavier Santos and Maria Santos and In{\^e}s Baldeiras and Catarina Resende de Oliveira and Paula I Moreira},
  booktitle={Diabetes},
  year={2012}
}
Evidence shows that diabetes increases the risk of developing Alzheimer's disease (AD). Many efforts have been done to elucidate the mechanisms linking diabetes and AD. To demonstrate that mitochondria may represent a functional link between both pathologies, we compared the effects of AD and sucrose-induced metabolic alterations on mouse brain mitochondrial bioenergetics and oxidative status. For this purpose, brain mitochondria were isolated from wild-type (WT), triple transgenic AD (3xTg-AD… CONTINUE READING

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