Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

Abstract

Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the strength of interaction between the T-cell receptor (TCR) and peptides presented by human leukocyte antigens… (More)
DOI: 10.3389/fimmu.2017.01516

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Cite this paper

@inproceedings{Jones2017MetabolicAO, title={Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation}, author={Nicholas Jones and James G. R. Cronin and Garry Dolton and Silvia Panetti and Andrea J. A. Schauenburg and Sarah A. E. Galloway and Andrew K Sewell and David K. Cole and Catherine A. Thornton and Nigel J. Francis}, booktitle={Front. Immunol.}, year={2017} }