Metabolic Adaptation Establishes Disease Tolerance to Sepsis

  title={Metabolic Adaptation Establishes Disease Tolerance to Sepsis},
  author={Sebastian Weis and Ana Rita Carlos and Maria Raquel Moita and Sumnima Singh and Birte Blankenhaus and Silvia E C Cardoso and Rasmus Hviid Larsen and Sofia P. Rebelo and Sascha Sch{\"a}uble and Laura Del Barrio and Gilles Mithieux and Fabienne Rajas and Sandro Lindig and Michael Bauer and Miguel P Soares},
Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is a defense strategy against infection that preserves host homeostasis without exerting a direct negative impact on pathogens. Here, we demonstrate that induction of the iron-sequestering ferritin H chain (FTH) in response to polymicrobial infections is critical to establish disease tolerance to sepsis. The protective effect of FTH is… CONTINUE READING
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