Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ

@article{ForystLudwig2008MetabolicAO,
  title={Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ},
  author={Anna Foryst-Ludwig and Markus Clemenz and Stephan Hohmann and Martin M Hartge and Christiane Sprang and Nikolaj Frost and Maxim Krikov and Sanjay Bhanot and Rodrigo P. A. Barros and Andrea Morani and Jan-{\AA}ke Gustafsson and Thomas Unger and Ulrich Kintscher},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={360 - 366}
}
Estrogen receptors (ER) are important regulators of metabolic diseases such as obesity and insulin resistance (IR). While ERalpha seems to have a protective role in such diseases, the function of ERbeta is not clear. To characterize the metabolic function of ERbeta, we investigated its molecular interaction with a master regulator of insulin signaling/glucose metabolism, the PPARgamma, in vitro and in high-fat diet (HFD)-fed ERbeta -/- mice (betaERKO) mice. Our in vitro experiments showed that… CONTINUE READING
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