Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.

@article{Curtin2009MetaAO,
  title={Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.},
  author={Karen Curtin and Wei-Yu Lin and Rina R George and Mark Katory and Jennifer Shorto and Lisa A. Cannon-Albright and D Timothy Bishop and Angela Cox and Nicola J. Camp},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2009},
  volume={18 2},
  pages={616-21}
}
BACKGROUND Genome-wide association studies of colorectal cancer (CRC) have identified genetic variants that reproducibly associate with CRC. Associations of 12 single nucleotide polymorphisms at 8q24, 9p24, and 18q21 (SMAD7) and CRC were investigated in a three-center collaborative study including two U.K. case-control cohorts (Sheffield and Leeds) and a U.S. case-control study of CRC cases from high-risk Utah pedigrees. METHODS Our combined resource included 1,092 CRC case subjects and 1,060… CONTINUE READING