Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials

@article{Schmidli2017MetaanalyticpredictiveUO,
  title={Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials},
  author={Heinz Schmidli and Beat Neuenschwander and Tim Friede},
  journal={Computational Statistics & Data Analysis},
  year={2017},
  volume={113},
  pages={100-110}
}
Continuous endpoints are common in clinical trials. The design and analysis of such trials is often based on models assuming normally distributed data, possibly after an appropriate transformation. When planning a new trial, information on the variance of the endpoint is usually available from historical trials. Although the idea to use historical data for a new trial is not new, literature on how to formally summarize and use these data on variances is scarce. The meta-analytic-predictive (MAP… CONTINUE READING

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