Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis

  title={Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis},
  author={Yukari Watanabe and Takamitsu Watanabe},
  journal={European Journal of Epidemiology},
Head injury is considered as a potential risk factor for amyotrophic lateral sclerosis (ALS). However, several recent studies have suggested that head injury is not a cause, but a consequence of latent ALS. We aimed to evaluate such a possibility of reverse causation with meta-analyses considering time lags between the incidence of head injuries and the occurrence of ALS. We searched Medline and Web of Science for case–control, cross-sectional, or cohort studies that quantitatively investigated… 

Head Injury and Amyotrophic Lateral Sclerosis: A Meta-Analysis

Although a strong association is found between head injury <1 year and ALS risk in the current study, this result suggests a possibility of reverse causation.

Trauma and amyotrophic lateral sclerosis: a systematic review and meta-analysis

This meta-analysis indicated that trauma could increase ALS risk, which may be applied for the clinicians to tailor targeted treatment regimens and make prophylactic strategies for ALS in traumatic patients.

Environmental risk factors for amyotrophic lateral sclerosis: a case–control study in Canada and France

Head trauma is a risk factor for ALS in men only, and previous occupation at high risk for pesticides exposure and electrocution are also risk factors for ALS.

Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

A population-based case-control study in four provinces from both Northern and Southern Italy suggests a potential etiologic role a number of clinical and lifestyle factors with ALS risk, however, caution is needed due to some study limitations.

Epidemiology of amyotrophic lateral sclerosis in Friuli-Venezia Giulia, North-Eastern Italy, 2002–2014: a retrospective population-based study

When assessed over a long period, incidence of ALS was in the range of Italian and European population-based registries and showed a consistent pattern by age and sex.

Chronic Traumatic Encephalopathy as a Preventable Environmental Disease

This Perspective explores the evolution of the understanding of chronic traumatic encephalopathy and its relationship with repetitive head injury and provides novel insights into mechanisms underlying abnormal protein accumulation in CTE and other neurodegenerative diseases.

Amyotrophic lateral sclerosis: the complex path to precision medicine

Although there are major gaps in the understanding of the essential nature of ALS pathophysiology, the identification of genetic causes in up to 15% of ALS patients, coupled with advances in biotechnology and biomarker research provide a foundation for approaches to treatment based on ‘precision medicine’, and even prevention of the disease in pre-symptomatic mutation carriers in the future.

Increased ISGylation in Cases of TBI-Exposed ALS Veterans

Using a Wes assay, it is shown that ISGylation, a conjugated form of interferon-stimulated gene 15 protein, is significantly elevated in the lumbar spinal cords of TBI-ALS compared with ALS veterans without a previous history ofTBI (nonTBI- ALS).

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

Brain atrophy is a key measure of disease progression and can be used to accurately quantify neuronal loss, anduid biomarkers such as neurofilament light can complement neuroimaging, representing sensitive potential methods to track neurodegenerative processes that develop after TBI.



Head injury and risk of Parkinson disease: A systematic review and meta‐analysis

The results of the meta‐analysis indicate that a history of head trauma that results in concussion is associated with a higher risk of developing PD.

Is head trauma a risk factor for amyotrophic lateral sclerosis? An evidence based review

  • C. ArmonL. Nelson
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2012
It is concluded that evidence based analysis of the epidemiologic literature does not permit concluding that a single instance of head trauma is a risk factor for, or causes, ALS.

Severe head injury and amyotrophic lateral sclerosis

The findings from the Swedish registers provide no strong support for an etiological relationship between severe head injury in adulthood and ALS risk.

Head injury and amyotrophic lateral sclerosis.

The notion that head injury may increase the risk of ALS is supported in a case-control study of New England ALS cases diagnosed in 1993-1996 and 255 matched controls and a meta-analysis of the published literature.

Traumatic Injury and Multiple Sclerosis: A Systematic Review and Meta-Analysis

  • S. WarrenS. A. Olivo K. Warren
  • Medicine, Psychology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2013
The findings support the conclusion that there is no association between traumatic injury and multiple sclerosis onset; more high quality cohort studies would help to confirm this observation.

Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies

The findings from this meta-analysis indicate that head injury is associated with increased risks of dementia and AD.

Head and other physical trauma requiring hospitalisation is not a significant risk factor in the development of ALS

Physical Trauma and Amyotrophic Lateral Sclerosis: A Population-Based Study Using Danish National Registries.

The data suggest that physical trauma at earlier ages is associated with ALS risk, and age at first trauma could help explain discrepancies in results of past studies of trauma and ALS.

Head injury and risk for Parkinson disease

The hypothesis that head injury increases the risk for Parkinson disease is not supported, as no association was observed between any head injury before first cardinal symptom and PD.

Head injury does not alter disease progression or neuropathologic outcomes in ALS

Head injury was not associated with faster disease progression in ALS and did not result in a specific neuropathologic phenotype, and the tau pathology described with chronic traumatic encephalopathy was found in ALS autopsy cases both with and without head injury.