Meta-analysis of the relevance of the <ce:italic>OPRM1</ce:italic> 118A>G genetic variant for pain treatment

  title={Meta-analysis of the relevance of the <ce:italic>OPRM1</ce:italic> 118A>G genetic variant for pain treatment},
  author={Carmen Walter and J{\"o}rn L{\"o}tsch},
Regard of functional pharmacogenetic polymorphisms may further the success of pain therapy by adopting individualized approaches. The mu-opioid receptor gene (OPRM1) 118A>G polymorphism is a promising candidate for both opioid effects and pain because of both biological reasonability and apparent experimental and clinical evidence. We analyzed its importance for pain therapy using a meta-analytic approach to studies relating it to opioid pain therapy. Data from suitable studies selected from… CONTINUE READING
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