Meta-analysis of the literature or of individual patient data: is there a difference?

@article{Stewart1993MetaanalysisOT,
  title={Meta-analysis of the literature or of individual patient data: is there a difference?},
  author={Lesley Anne Stewart and M. K. Parmar},
  journal={Lancet},
  year={1993},
  volume={341 8842},
  pages={418-22}
}
The use of meta-analyses or overviews to combine formally the results of related randomised clinical trials is becoming increasingly common. However the distinction between analyses based on information extracted from the published literature and those based on collecting and reanalysing updated individual patient data is not clear. We have investigated the difference between meta-analysis of the literature (MAL) and meta-analysis of individual patient data (MAP) by comparing the two approaches… CONTINUE READING
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