Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion/deletion polymorphism as a risk factor for preeclampsia.

@article{Pabalan2015MetaanalysisOT,
  title={Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion/deletion polymorphism as a risk factor for preeclampsia.},
  author={Noel Pabalan and Hamdi Jarjanazi and Chen Sun and Ann-Charlotte Iversen},
  journal={Tissue antigens},
  year={2015},
  volume={86 3},
  pages={186-94}
}
The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the uterine wall, to ensure successful placental development and function. Several HLA-G gene variants have been shown to be associated with development of preeclampsia (PE), but the reported associations of the HLA-G 14 base pair (bp) insertion/deletion (I/D) polymorphism… CONTINUE READING
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