Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes.

@article{Brunelle1998MetaanalysisOT,
  title={Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes.},
  author={B L Brunelle and John Llewelyn and James H. Anderson and Edwin A. M. Gale and Veikko A. Koivisto},
  journal={Diabetes care},
  year={1998},
  volume={21 10},
  pages={1726-31}
}
OBJECTIVE A precise time-action profile of insulin lispro (Humalog) at mealtime may reduce the incidence of severe hypoglycemia. Because it is a rare complication, we performed a cumulative meta-analysis to compare the frequency of severe hypoglycemia during insulin lispro and human regular insulin therapy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS The analysis included eight large multi-center clinical trials, three with parallel and five with crossover designs. The studies… CONTINUE READING

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Statistical methods for meta-analysis

  • LV Hedges, I. Olkin
  • New Engl J Med
  • 1985

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