Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder
@article{Lin2007MetaanalysisOT, title={Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder}, author={Pao-Yen Lin}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2007}, volume={31}, pages={683-689} }
80 Citations
Lack of Evidence For Association Between Serotonin Transporter Gene Polymorphism and Obsessive Compulsive Disorder fienel
- Biology, Psychology
- 2010
The authors could not find any evidence for the association of 5-HTTLPR and 5- HTT VNTR polymorphisms with OCD, response to treatment with serotonin reuptake inhibitors, positive family history for OCD and presence of tics.
Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population
- Biology, PsychologyThe Indian journal of medical research
- 2010
Genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population of OCD patients and controls of south Indian origin.
Is serotonin transporter polymorphism (5-HTTLPR) allele status a predictor for obsessive-compulsive disorder? A meta-analysis
- Psychology, BiologyArchives of Women's Mental Health
- 2015
The findings provide further support for the need of subtype classification of this heterogeneous disorder and emphasis should be placed on the effect of female reproductive milestones on OCD onset and symptom exacerbation.
Association of the functional serotonin transporter haplotype with familial form of obsessive compulsive disorder in Iranian patients
- Psychology, BiologyInternational journal of psychiatry in clinical practice
- 2018
The association of SLC6A4 variants with familial form of OCD was showed and proposed stratified analyses in the genetic studies facilitate identification of genetic risk factors for this heterogeneous disorder.
Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review
- Psychology, BiologyAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2008
The meta‐analysis suggests the possibility that the l‐allele may be associated with OCD in specific OCD subgroups such as childhood‐onset OCD and in Caucasians, and demonstrates a significant association between the l-allele and OCD in family‐based association studies and in studies involving children and Caucasians.
Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
- Biology, PsychologyMolecular Psychiatry
- 2013
It is demonstrated that OCD is associated with multiple genes, with most having a modest association with OCD, which suggests a polygenic model of OCD, consistent with twin studies, in which multiple genes make small, incremental contributions to the risk of developing the disorder.
Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.
- Biology, PsychologyJournal of psychiatric research
- 2018
Association study between obsessive–compulsive disorder and serotonergic candidate genes
- Biology, PsychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2008
Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder
- Biology, PsychologyThe Clinical neuropsychologist
- 2016
The findings suggest that the high-expressing variant of 5-HTTLPR polymorphism may be associated with lower performance on some abstraction and planning measures in OCD patients.
Association of SLC6A4 variants with obsessive-compulsive disorder in a large multi-center US family study
- BiologyMolecular Psychiatry
- 2011
Evidence is found of genetic association at the SLC6A4 locus with OCD using the Family-Based Association Test (FBAT) under additive, dominant, recessive and genotypic models, using both OCD and sex-stratified OCD as phenotypes.
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The SERTPR polymorphisms affect certain factors of OC symptoms, and the factor analytic approach used in the present study has identified meaningful symptom dimensions to help guide future research.
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