Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder

@article{Lin2007MetaanalysisOT,
  title={Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder},
  author={Pao-Yen Lin},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2007},
  volume={31},
  pages={683-689}
}
  • Pao-Yen Lin
  • Published 13 April 2007
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
View on Elsevier
doi.org
80 Citations
Highly Influential Citations
5
Background Citations
29
Methods Citations
2
Results Citations
5

80 Citations

Lack of Evidence For Association Between Serotonin Transporter Gene Polymorphism and Obsessive Compulsive Disorder fienel
TLDR
The authors could not find any evidence for the association of 5-HTTLPR and 5- HTT VNTR polymorphisms with OCD, response to treatment with serotonin reuptake inhibitors, positive family history for OCD and presence of tics.
Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population
TLDR
Genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population of OCD patients and controls of south Indian origin.
Is serotonin transporter polymorphism (5-HTTLPR) allele status a predictor for obsessive-compulsive disorder? A meta-analysis
TLDR
The findings provide further support for the need of subtype classification of this heterogeneous disorder and emphasis should be placed on the effect of female reproductive milestones on OCD onset and symptom exacerbation.
Association of the functional serotonin transporter haplotype with familial form of obsessive compulsive disorder in Iranian patients
TLDR
The association of SLC6A4 variants with familial form of OCD was showed and proposed stratified analyses in the genetic studies facilitate identification of genetic risk factors for this heterogeneous disorder.
Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review
  • M. Bloch, A. Landeros-Weisenberger, J. Leckman
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
The meta‐analysis suggests the possibility that the l‐allele may be associated with OCD in specific OCD subgroups such as childhood‐onset OCD and in Caucasians, and demonstrates a significant association between the l-allele and OCD in family‐based association studies and in studies involving children and Caucasians.
Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
  • S. Taylor
  • Biology, Psychology
    Molecular Psychiatry
  • 2013
TLDR
It is demonstrated that OCD is associated with multiple genes, with most having a modest association with OCD, which suggests a polygenic model of OCD, consistent with twin studies, in which multiple genes make small, incremental contributions to the risk of developing the disorder.
Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.
Association study between obsessive–compulsive disorder and serotonergic candidate genes
Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder
TLDR
The findings suggest that the high-expressing variant of 5-HTTLPR polymorphism may be associated with lower performance on some abstraction and planning measures in OCD patients.
Association of SLC6A4 variants with obsessive-compulsive disorder in a large multi-center US family study
TLDR
Evidence is found of genetic association at the SLC6A4 locus with OCD using the Family-Based Association Test (FBAT) under additive, dominant, recessive and genotypic models, using both OCD and sex-stratified OCD as phenotypes.
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References

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TLDR
Haplotype-based haplotype relative risk and transmission disequilibrium analysis did not show a preferential transmission of l allele to OCD probands, indicating the need to analyse larger samples using family-based methods.
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved…
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TLDR
A trend toward positive association between the fifth factor, including counting and repeating rituals, and 5-HTTLPR was found, but only considering the subgroup of patients with tic codiagnosis, it is found a significantly higher score for thefifth factor for patients with L/L genotype with respect to L/S and S/S genotypes.
Obsessive-compulsive disorder and the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population.
TLDR
Evidence that variation in SLC6A4 plays a significant role in the development of OCD in the population groups studied is inconclusive, and future association studies in Caucasian populations may extend the power of such meta-analyses and assist in delineating the role of SLC 6A4 in OCD.
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