Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder

@article{Lin2007MetaanalysisOT,
  title={Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder},
  author={Pao-Yen Lin},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2007},
  volume={31},
  pages={683-689}
}
  • Pao-Yen Lin
  • Published 13 April 2007
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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The findings provide further support for the need of subtype classification of this heterogeneous disorder and emphasis should be placed on the effect of female reproductive milestones on OCD onset and symptom exacerbation.
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The association of SLC6A4 variants with familial form of OCD was showed and proposed stratified analyses in the genetic studies facilitate identification of genetic risk factors for this heterogeneous disorder.
Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review
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  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
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Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
  • S. Taylor
  • Biology, Psychology
    Molecular Psychiatry
  • 2013
TLDR
It is demonstrated that OCD is associated with multiple genes, with most having a modest association with OCD, which suggests a polygenic model of OCD, consistent with twin studies, in which multiple genes make small, incremental contributions to the risk of developing the disorder.
Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.
Association study between obsessive–compulsive disorder and serotonergic candidate genes
Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder
TLDR
The findings suggest that the high-expressing variant of 5-HTTLPR polymorphism may be associated with lower performance on some abstraction and planning measures in OCD patients.
Association of SLC6A4 variants with obsessive-compulsive disorder in a large multi-center US family study
TLDR
Evidence is found of genetic association at the SLC6A4 locus with OCD using the Family-Based Association Test (FBAT) under additive, dominant, recessive and genotypic models, using both OCD and sex-stratified OCD as phenotypes.
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References

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Haplotype-based haplotype relative risk and transmission disequilibrium analysis did not show a preferential transmission of l allele to OCD probands, indicating the need to analyse larger samples using family-based methods.
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved
Obsessive-Compulsive Disorder, Factor-Analyzed Symptom Dimensions and Serotonin Transporter Polymorphism
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The SERTPR polymorphisms affect certain factors of OC symptoms, and the factor analytic approach used in the present study has identified meaningful symptom dimensions to help guide future research.
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TLDR
A trend toward positive association between the fifth factor, including counting and repeating rituals, and 5-HTTLPR was found, but only considering the subgroup of patients with tic codiagnosis, it is found a significantly higher score for thefifth factor for patients with L/L genotype with respect to L/S and S/S genotypes.
Obsessive-compulsive disorder and the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population.
TLDR
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