Meta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disorders

@article{Bandelow2007MetaanalysisOR,
  title={Meta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disorders},
  author={Borwin Bandelow and Ulrich Seidler-Brandler and Andreas Becker and Dirk Wedekind and Eckart Rüther},
  journal={The World Journal of Biological Psychiatry},
  year={2007},
  volume={8},
  pages={175 - 187}
}
Background. A number of meta-analyses have led to contradictory results regarding the efficacy of the psychological and pharmacological treatment of anxiety disorders. The main reasons for these inconsistent results seem to be the inclusion of heterogeneous studies and influences of selection biases. We performed a meta-analysis, which only included studies using a direct comparison of pharmacological, psychological, or combined treatments. Method. Sixteen studies on panic disorder, six studies… 
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References

SHOWING 1-10 OF 119 REFERENCES
A meta-analysis of treatments for panic disorder.
TLDR
In a meta-analysis, the authors compared the effectiveness of psychological and pharmacological treatments for panic disorder, finding psychological coping strategies involving relaxation training, cognitive restructuring, and exposure yielded the most consistent ESs.
A controlled trial of treatments for generalized anxiety.
TLDR
This study tested the relative effectiveness of cognitive-behavioural therapy, anxiety management training and treatment by benzodiazepines against a waiting list control and found no difference between the two groups receiving psychological treatments.
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments.
TLDR
The combination of antidepressants with exposure in vivo is the most potent short-term treatment of PA, and all seven treatments were superior to the control condition for panic attacks.
Psychological and Pharmacological Treatments of Social Phobia: A Meta-Analysis
TLDR
BDZs and SSRIs seem to be effective treatments for social phobia, at least in the short term, while assessing the long-term outcome for pharmacotherapies and evaluating the inclusion of a cognitive-behavioral treatment during the drug tapering period.
Cognitive-Behavioral and Pharmacological Treatment for Social Phobia: A Meta-Analysis
TLDR
According to cost projections, group cognitive-behavioral treatment offered the most cost-effective intervention and selective serotonin reup-take inhibitors and benzodiazepines yielded the largest effect sizes for pharmacotherapy.
Controlled comparison of pharmacological and psychological treatment of generalized anxiety disorder in primary care.
TLDR
Cognitive-behaviour therapy, either alone or in combination with drug or placebo, showed the lowest incidence of referral for psychological or psychiatric treatment at six months follow-up.
A multidimensional meta-analysis of treatments for depression, panic, and generalized anxiety disorder: an empirical examination of the status of empirically supported therapies.
TLDR
A meta-analysis of high-quality studies published from 1990-1998 on the efficacy of manualized psychotherapies for depression, panic disorder, and generalized anxiety disorder suggests that a substantial proportion of patients with panic improve and remain improved.
A comparison of bibliotherapy and group therapy in the treatment of panic disorder.
TLDR
This study investigated 2 methods of disseminating a cognitive-behavioral intervention for panic disorder and found that both the BT and GT treatments were more effective than the WL condition in reducing frequency of panic attacks, severity of physical panic symptoms, catastrophic cognitions, agoraphobic avoidance, and depression.
Global measures of outcome in a controlled comparison of pharmacological and psychological treatment of panic disorder and agoraphobia in primary care.
TLDR
Results indicate that treatments including cognitive behaviour therapy can be effective in the treatment of panic disorder and agoraphobia in primary care, with statistically significant advantages over placebo over a range of outcome ratings.
...
...