Meta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disorders

@article{Bandelow2007MetaanalysisOR,
  title={Meta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disorders},
  author={Borwin Bandelow and Ulrich Seidler-Brandler and Andreas Becker and Dirk Wedekind and Eckart Rüther},
  journal={The World Journal of Biological Psychiatry},
  year={2007},
  volume={8},
  pages={175 - 187}
}
Background. A number of meta-analyses have led to contradictory results regarding the efficacy of the psychological and pharmacological treatment of anxiety disorders. The main reasons for these inconsistent results seem to be the inclusion of heterogeneous studies and influences of selection biases. We performed a meta-analysis, which only included studies using a direct comparison of pharmacological, psychological, or combined treatments. Method. Sixteen studies on panic disorder, six studies… 
View on Taylor & Francis
coping.us
120 Citations
Highly Influential Citations
4
Background Citations
32
Methods Citations
4
Results Citations
7

120 Citations

Citation Type

Citation Type

Efficacy of treatments for anxiety disorders: a meta-analysis
TLDR
In direct comparisons with control groups, all investigated drugs, except for citalopram, opipramol and moclobemide, were significantly more effective than placebo; this finding cannot be explained by heterogeneity, publication bias or allegiance effects.
Pharmacological and psychological interventions for generalized anxiety disorder in adults: A network meta-analysis.
Efficacy of pharmacotherapy and psychotherapy for adult psychiatric disorders: a systematic overview of meta-analyses.
TLDR
The quality of the individual trials included in the pharmacotherapy and psychotherapy meta-analyses was assessed with the Cochrane risk of bias tool and effect sizes of psychotherapies vs placebo tended to be higher than those of medication, but direct comparisons did not reveal consistent differences.
Yoga in the treatment of mood and anxiety disorders: A review.
Does adding pharmaceutical medication contribute to empirically supported psychological treatment for anxiety disorders?
TLDR
It is concluded that adding PT to EST does not improve the results but it does increase the cost and duration of treatment, thereby reducing the efficiency of the intervention.
A Meta–Analytic Review of Psychological Treatments for Social Anxiety Disorder
This meta–analysis multiple well-controlled studies were combined to help clarify the overall impact of psychological treatments for social anxiety disorder. A comprehensive literature search…
Comparison of combined psycho- and pharmacotherapy with monotherapy in anxiety disorders: controversial viewpoints and clinical perspectives
TLDR
It is suggested that a research strategy that strives to establish differential indications based on patient characteristics should be preferred over attempts to reach a global judgement of the question, which appears too simplistic given the complexity of the issue.
Pharmaceutical Management of General Anxiety Disorder
TLDR
A thorough and comprehensive review of the different approaches of GAD management is provided, taking into account the cost effectiveness of the treatment, patient’s symptomatology, comorbidity, medical conditions, concomitant using medications, previous trials and preference.
Combined Treatment With CBT and Psychopharmacology
The Biology and Efficacy of Combination Strategies for Anxiety Disorders
Optimal treatment of anxiety disorders is important as they are the most prevalent psychiatric disorders in community studies, and generalized anxiety disorder is themost prevalent psychiatric…
...
...

References

SHOWING 1-10 OF 119 REFERENCES
Interaction of pharmacological and psychological treatments of anxiety
TLDR
There is some evidence that short-term, combined treatment does confer additional benefits which are evident both in speed of onset and lasting remission in generalised anxiety disorder.
A meta-analysis of treatment outcome for panic disorder
A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia.
  • Kristin Mitte
  • Psychology, Medicine
    Journal of affective disorders
  • 2005
A meta-analysis of treatments for panic disorder.
TLDR
In a meta-analysis, the authors compared the effectiveness of psychological and pharmacological treatments for panic disorder, finding psychological coping strategies involving relaxation training, cognitive restructuring, and exposure yielded the most consistent ESs.
A controlled trial of treatments for generalized anxiety.
TLDR
This study tested the relative effectiveness of cognitive-behavioural therapy, anxiety management training and treatment by benzodiazepines against a waiting list control and found no difference between the two groups receiving psychological treatments.
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments.
TLDR
The combination of antidepressants with exposure in vivo is the most potent short-term treatment of PA, and all seven treatments were superior to the control condition for panic attacks.
Psychological and Pharmacological Treatments of Social Phobia: A Meta-Analysis
TLDR
BDZs and SSRIs seem to be effective treatments for social phobia, at least in the short term, while assessing the long-term outcome for pharmacotherapies and evaluating the inclusion of a cognitive-behavioral treatment during the drug tapering period.
Cognitive-Behavioral and Pharmacological Treatment for Social Phobia: A Meta-Analysis
TLDR
According to cost projections, group cognitive-behavioral treatment offered the most cost-effective intervention and selective serotonin reup-take inhibitors and benzodiazepines yielded the largest effect sizes for pharmacotherapy.
A comparison of alprazolam and behavior therapy in treatment of panic disorder.
The results of a clinical outcome study (N = 57) comparing behavior therapy directed at panic disorder (panic control treatment [PCT]) with alprazolam were reported. These conditions were compared…
Controlled comparison of pharmacological and psychological treatment of generalized anxiety disorder in primary care.
TLDR
Cognitive-behaviour therapy, either alone or in combination with drug or placebo, showed the lowest incidence of referral for psychological or psychiatric treatment at six months follow-up.
...
...