Meta-analysis of published transcriptional and translational fold changes reveals a preference for low-fold inductions.

@article{Wren2006MetaanalysisOP,
  title={Meta-analysis of published transcriptional and translational fold changes reveals a preference for low-fold inductions.},
  author={Jonathan D. Wren and Tyrrell Conway},
  journal={Omics : a journal of integrative biology},
  year={2006},
  volume={10 1},
  pages={15-27}
}
The goals of this study were to gain a better quantitative understanding of the dynamic range of transcriptional and translational response observed in biological systems and to examine the reporting of regulatory events for trends and biases. A straightforward pattern-matching routine extracted 3,408 independent observations regarding transcriptional fold-changes and 1,125 regarding translational fold-changes from over 15 million MEDLINE abstracts. Approximately 95% of reported changes were… CONTINUE READING

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