Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

@inproceedings{Vilardell2010MetaanalysisOH,
  title={Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes},
  author={Mireia Vilardell and Axel Rasche and Anja Thormann and Elisabeth Maschke-Dutz and Luis A. P{\'e}rez-Jurado and Hans Lehrach and Ralf Herwig},
  booktitle={BMC Genomics},
  year={2010}
}
Down syndrome (DS; trisomy 21) is the most common genetic cause of mental retardation in the human population and key molecular networks dysregulated in DS are still unknown. Many different experimental techniques have been applied to analyse the effects of dosage imbalance at the molecular and phenotypical level, however, currently no integrative approach exists that attempts to extract the common information. We have performed a statistical meta-analysis from 45 heterogeneous publicly… CONTINUE READING

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