Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  title={Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes},
  author={Eleftheria Zeggini and Laura J. Scott and R Singh Saxena and Benjamin F. Voight and Jonathan Marchini and Tianle Hu and Paul I. W. de Bakker and Gonçalo R. Abecasis and Peter Almgren and Gitte Andersen and Kristin G. Ardlie and Kristina Bengtsson Bostr{\"o}m and Richard N Bergman and Lori L. Bonnycastle and Knut Borch-Johnsen and No{\"e}l P. Burtt and Hong Chen and Peter S. Chines and Mark J. Daly and Parimal A. Deodhar and Chia-Jen Ding and Alex S. F. Doney and William Duren and Katherine S. Elliott and Michael R Erdos and Timothy M. Frayling and Rachel M Freathy and Lauren Gianniny and Harald Grallert and Niels Grarup and Christopher James Groves and Candace Guiducci and Torben Hansen and Christian Herder and Graham A. Hitman and Thomas E Hughes and Bo Isomaa and Anne U. Jackson and Torben J\orgensen and Augustine Kong and Kari A Kubalanza and Finny G. Kuruvilla and Johanna Kuusisto and Claudia Langenberg and Hana Lango and T Lauritzen and Yun Li and Cecilia M. Lindgren and Valeriya Lyssenko and Amanda F. Marvelle and Christa Meisinger and Kristian Midthjell and Karen L. Mohlke and Mario A. Morken and Andrew D. Morris and Narisu Narisu and Peter Nilsson and K Owen and Colin N A Palmer and Felicity Payne and John R. B. Perry and Elin Pettersen and Carl G. P. Platou and Inga Prokopenko and Lu Qi and Li Qin and Nigel William Rayner and Matthew G. Rees and Jeffrey J. Roix and Anelli Sandb{\ae}k and Beverley M Shields and Marketa Sj{\"o}gren and Valgerdur Steinthorsdottir and Heather M Stringham and Amy J. Swift and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Nicholas J. Timpson and Tiinamaija Tuomi and Jaakko Tuomilehto and Mark Walker and Richard M. Watanabe and M. N. Weedon and Cristen J. Willer and Thomas Illig and Kristian Hveem and Frank B Hu and Markku Laakso and K{\'a}ri Stef{\'a}nsson and Oluf Pedersen and Nicholas J Wareham and In{\^e}s Barroso and Andrew T Hattersley and Francis S. Collins and Leif Groop and Mark I. McCarthy and Michael Boehnke and David Altshuler},
  journal={Nature Genetics},
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and ∼2.2 million SNPs (directly… CONTINUE READING
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