Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

  title={Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease},
  author={K. Lohmueller and C. L. Pearce and M. Pike and E. Lander and J. Hirschhorn},
  journal={Nature Genetics},
  • K. Lohmueller, C. L. Pearce, +2 authors J. Hirschhorn
  • Published 2003
  • Biology, Medicine
  • Nature Genetics
  • Association studies offer a potentially powerful approach to identify genetic variants that influence susceptibility to common disease, but are plagued by the impression that they are not consistently reproducible. In principle, the inconsistency may be due to false positive studies, false negative studies or true variability in association among different populations. The critical question is whether false positives overwhelmingly explain the inconsistency. We analyzed 301 published studies… CONTINUE READING
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