Meta-analysis of folic acid efficacy trials in stroke prevention
@article{Zhao2017MetaanalysisOF, title={Meta-analysis of folic acid efficacy trials in stroke prevention}, author={Min Zhao and Guangliang Wu and Youbao Li and Xiaobin Wang and Fan Fan Hou and Xiping Xu and Xianhui Qin and Yefeng Cai}, journal={Neurology}, year={2017}, volume={88}, pages={1830 - 1838} }
Objective: To examine the efficacy and effect modifiers of folic acid supplementation in the prevention of stroke in regions without folic acid fortification based on relevant, up-to-date published randomized trials. Methods: Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of stroke using a fixed effects model. Findings: Overall, folic acid supplementation significantly reduced the stroke risk by 11% (22 trials, n = 82,723; RR 0.89, 95% confidence…
34 Citations
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A focused Medline search of the English language literature was conducted between 2010 and 2017 using the terms, homocysteine, risk factor, atherosclerosis, cardiovascular disease, stroke, treatment, and 38 papers with pertinent information were selected and there is a controversy regarding the significance of homocy steine as a risk factor for CVD and stroke.
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References
SHOWING 1-10 OF 44 REFERENCES
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
- Medicine, PsychologyThe Lancet
- 2007
Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials
- MedicineJournal of the American Heart Association
- 2016
A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels, while folic acid supplementation had no significant effect on risk of coronary heart disease.
Secondary prevention with folic acid: effects on clinical outcomes.
- MedicineJournal of the American College of Cardiology
- 2003
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.
- MedicineJAMA
- 2007
Folic acid at 1 mg/d does not reduce colorectal adenoma risk and is associated with higher risks of having 3 or more adenomas and of noncolorectAL cancers.
Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial.
- MedicineAmerican journal of epidemiology
- 1996
It is indicated that supplementation with a multivitamin/mineral combination may have reduced mortality from cerebrovascular disease and the prevalence of hypertension in this rural population with a micronutrient-poor diet.
Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial.
- Medicine, PsychologyJAMA
- 2015
Among adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid, compared with en alapril alone, significantly reduced the risk of first stroke.
Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial.
- MedicineInternational journal of cardiology
- 2004
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials.
- MedicineThe American journal of clinical nutrition
- 2005
The objectives were to ascertain the lowest dose of folic acid associated with the maximum reduction in homocysteine concentrations and to determine the additional relevance of vitamins B-12 and B-6.
Folic Acid-Based Intervention in Non-ST Elevation Acute Coronary Syndromes
- MedicineAsian cardiovascular & thoracic annals
- 2009
Folic acid-based supplementation is not beneficial and may even be harmful in the secondary prevention of cardiovascular events in patients with unstable angina and non-ST-elevation myocardial infarction and further studies on the safety of such supplements are suggested.
Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial.
- MedicineJAMA
- 2010
Among patients with diabetic nephropathy, high doses of B vitamins compared with placebo resulted in a greater decrease in GFR and an increase in vascular events.