Meta-analysis of folic acid efficacy trials in stroke prevention

  title={Meta-analysis of folic acid efficacy trials in stroke prevention},
  author={Min Zhao and Guangliang Wu and Youbao Li and Xiaobin Wang and Fan Fan Hou and Xiping Xu and Xianhui Qin and Yefeng Cai},
  pages={1830 - 1838}
Objective: To examine the efficacy and effect modifiers of folic acid supplementation in the prevention of stroke in regions without folic acid fortification based on relevant, up-to-date published randomized trials. Methods: Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of stroke using a fixed effects model. Findings: Overall, folic acid supplementation significantly reduced the stroke risk by 11% (22 trials, n = 82,723; RR 0.89, 95% confidence… 

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