Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness.

  title={Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness.},
  author={Stephen W. Looney and Rif S. El-Mallakh},
  journal={Depression and anxiety},
  volume={5 2},
Sodium, potassium-activated adenosine triphosphatase (Na,K-ATPase) pump activity has been variously reported to be increased, decreased, or unchanged in bipolar patients. To explore this association we conducted a meta-analysis of the available literature. All papers containing data on erythrocyte Na,K-ATPase activity were reviewed independently by both authors. A meta-analysis of these data was accomplished by standard procedure. We found a significant mood-state-related decrease in Na,K… CONTINUE READING