Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes.

@article{Wang1993MetaanalysisOE,
  title={Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes.},
  author={Ping Wang and Joseph Lau and Thomas C. Chalmers},
  journal={Lancet},
  year={1993},
  volume={341 8856},
  pages={1306-9}
}
Tight blood glucose control has been speculated to reduce late complications in insulin-dependent diabetics but results from individual studies have been inconsistent. We have done a meta-analysis of sixteen randomised trials of intensive therapy to estimate its impact on the progression of diabetic retinopathy and nephropathy and the risks of severe side-effects. In the intensive therapy group, the risk of retinopathy progression was insignificantly higher after 6-12 months of intensive… CONTINUE READING

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